ISEV is pleased to announce our 2017 Plenary Speakers!
Dr. Philip Stahl
Edward Mallinckrodt Jr. Professor emeritus
Cell Biology and Physiology
Washington University School of Medicine
St. Louis, MO
Dr. Stahl’s research spans nearly 5 decades at Washington University in St. Louis. Initially focused on lysosomal enzymes and lysosome biogenesis, the Stahl Laboratory and its many students have made a number of seminal contributions to our understanding of endocytosis, membrane trafficking and cell signaling. These include (i) the discovery of a sugar-specific lysosomal enzyme clearance pathway (in vivo) and the isolation and molecular cloning of the mannose receptor, the first member of a new family of sugar-specific pattern recognition receptors now considered components of the innate immune system; (ii) key advances in our understanding of Rab5 and Arf6, GTPases that orchestrate and regulate endosome fusion, endocytosis and receptor recyclingand especially growth factor receptor signaling and trafficking (iii) the cell biology of TBC1D3, a unique hominoid-specific gene that is highly multi-copied in thehuman genome. TBC1D3 regulates growth factor receptor ubiquitination thereby altering receptor trafficking and signaling. The influence of hominoid- and humanspecific genes on the human condition represents an unexplored frontier in cell biology. Lastly, (iv) the discovery of the “exosome secretion pathway” and the demonstration that multivesicular bodies release intraluminal vesicles to the extracellular compartment by fusing directly with the plasma membrane.
Dr. Thomas Thum
Faculty of Medicine, National Heart & Lung Institute
Professor of Cardiology
Imperial College, London, United Kingdom
Thomas Thum is Professor and Director of the Institute of Molecular and Translational Therapeutic Strategies at Hannover Medical School in Germany. Recently, he joined Imperial College as Visiting Professor to strengthen collaborative research activities.
Professor Thum studied Medicine at the Hannover Medical School and received a PhD from the Imperial College London and as a clinician is specialized in Internal Medicine and Cardiology. His major translational interests are to uncover the roles of regulatory RNA molecules, such as microRNAs and long-non-coding RNAs in cardiovascular and transplantation medicine. He is particularly interested into heart failure and performed landmark studies to show the therapeutic and diagnostic potential of microRNAs and respective antagonists. Prof. Thum published over 150 papers in leading scientific journals such as Nature, Nature Genetics, Nature Communication, Lancet, JACC and Circulation. He is member of the Editorial Board of many journals such as Circulation Research, ATVB or the Journal of Molecular and Cellular Cardiology. Prof. Thum is active member of many task forces and nuclei of cardiovascular societies including those of the European Society of Cardiology and the International Society of Heart Research. Prof. Thum is recipient of many national and international awards, e.g. the Outstanding Achievement Award from the European Society of Cardiology. He is coordinator and co-coordinator of several international consortia, e.g. for an intercontinental grant obtained from the Fondation Leducq or the European Union.
Dr. Jeff Wrana
The Lunenfeld-Tanenbaum Research Institute
Mount Sinai Hospital
Dr. Wrana’s research aims to expose the mechanisms involved in the development of these networks and to reveal new targets for treatments that would attack the entire disease network, not just individual hubs. Dr. Wrana's research program involves the application of high-throughput, robotics-based technologies that perform thousands of tests at a time and enable studies of gene function on a genome-wide scale. With his special expertise and phenomenal success securing support from granting agencies, he has established a Robotics Facility at the Lunenfeld-Tanenbaum Research Institute. The expertise and advanced technology available in the facility extends the research capacity of scientists throughout the Lunenfeld and beyond. Dr. Wrana has made significant discoveries in breast, colorectal and other cancers. In particular, he is interested in mechanisms of metastasis. Insights into this little-understood process have the potential to make a significant impact on survival rates for breast and other cancers.
Dr. Clotilde Théry
After a PhD in France, and a first post-doc in UK and USA on developmental biology of the nervous system, Clotilde Théry switched to the cell biology of immune responses when joining the Institut Curie, in Paris, France, in 1996. She soon started studying the nature and functions of exosomes secreted by immune and tumor cells, at a time where these entities were considered by a majority of scientists as uninteresting artifacts! She performed and published the first proteomic studies of exosomes secreted by immune dendritic cells (J Cell Biol 1999; J Immunol 2001), and went on to demonstrate how these cells can spread MHC-peptides complexes through exosomes, and thus help initiate immune responses (Nature Immmunol 2002; Blood 2005; J Immunol 2007). Since 2007, she has been leading a team entitled « Exosomes and tumor growth » at Institut Curie, Paris, France, in the “Immunity and Cancer” INSERM department. Her team focuses on unraveling the in vivo physiological or pathological functions of exosomes, and more recently of the other extracellular vesicles, by continuously going from cell biology approaches of their modes of formation to application of this knowledge to in vivo situations (Cancer Res 2008; Nature Cell Biol 2010, Cancer Res 2012; J Cell Sci 2013; PNAS 2016). Over the years, she has been invited to write several comprehensive reviews and opinion articles on the subject of exosomes, EVs, their immune and cancer-related functions and their biogenesis (Nature Rev Immunol 2009; Traffic 2011; Curr Op Cell Biol 2014, Annual Rev Cell Dev Biol 2014, Cell 2016). After organizing the first international workshop on exosomes in 2011 in Paris, C. Théry became co-founder and Secretary General of the International Society for Extracellular Vesicles (ISEV) from 2012 until 2016, and is co-editor in chief of the Journal of Extracellular Vesicles, since its creation in 2012.
Dr. Juan S. Bonifacino
NIH Distinguished Investigator
National Institutes of Health (NIH)
After receiving his PhD in biochemistry from the University of Buenos Aires, Argentina, Dr. Bonifacino moved to the US to work at the NIH. Since the early 1990s, Dr. Bonifacino's group at the NIH has been conducting research on signals and adaptors that mediate the sorting of proteins to endosomes, lysosomes, lysosome-related organelles such as melanosomes, and different domains of the plasma membrane in polarized cells such as neurons. His group discovered new sorting signals and adaptor proteins, and applied this knowledge to the elucidation of the causes of various disease conditions. In addition, Dr. Bonifacino’s group identified novel components of the molecular machinery involved in retrograde transport from endosomes to the trans-Golgi network (TGN), and in recycling from endosomes to the plasma membrane. Dr. Bonifacino is currently investigating the molecular mechanisms that control the movement of endosomes and lysosomes in non-neuronal and neuronal cells, and the connection of these mechanisms to neurodevelopmental and neurodegenerative disorders.
Dr. Polly Matzinger
Dr. Matzinger is an immunologist with revolutionary ideas about what triggers the immune system. She earned her doctorate at the University of California, San Diego. Matzinger then worked in the UK at the University of Cambridge and in Switzerland at the Basel Institute for Immunology before starting a lab at the US National Institutes of Health. She became a section head at the US National Institute of Allergy and Infectious Diseases. Matzinger is well known for the Danger Model of immunity as an alternative to the self/non-self recognition model. Interviewed by the New York Times, Matzinger said of science that "It's art. Actually, it's a sandbox and scientists get to play all of our lives."
Dr. Steve Lindow
Professor of Plant Pathology
Department of Plant and Microbial Biology, University of California, Berkeley
Berkeley, California, USA
The Lindow lab focuses on the ecology and molecular biology of bacteria that live in and on plants. Bacterial adaptations that distinguish epiphytic bacteria that live on the surface of plants such as quorum sensing mechanisms leading to bacterial aggregations that along with other phenotypes such as plant hormone and biosurfactant production lead to modifications of the microhabitats in which bacteria live on leaves are a focus of a variety of studies. We also are investigating cell density -dependent behaviors of the vascular plant pathogen Xylella fastidiosa with special reference to a fatty acid-based quorum sensing system that modulates its interaction with both the plant as well as insect vectors. Quorum sensing-dependent release of outer membrane vesicles that inhibit the attachment of cells of this pathogen to surfaces are important virulence factors, enabling the efficient movement of the pathogen between xylem vessels within plants. Plant disease control strategies based on “pathogen confusion” whereby fatty acid signaling molecules are artificially increased in plants are being developed.