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Program | Education Day | Plenary Speakers

 Click here to view the ISEV2018 Final Program

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Main Conference Program Preview

  3-6 May, 2018

The International Society for Extracellular Vesicles offers a multi-track program that will cater to researchers and attendees of all different backgrounds and education needs. The compact and flexible program allows for attendees to receive the maximum education while having enough time to explore the city of Barcelona! The preliminary program preview is available below and subject to change.

ISEV is proud to be co-hosting its 2018 Annual Meeting with GEIVEX and are grateful for the contribution of its members to the International Organizing Committee as part of ISEV2018!


 Wednesday, 2 May 2018 - ISEV 2018 Education Day

07:30 - 20:00 Registration and Information Desk

08:30 - 18:00

Education  Day Track A:  EVs in Biology and Technology

Room 6

08:30 - 18:00 

Education Day Track B:  EVs in Health and Disease

Room 5

18:00 - 20:30

Satellite Symposium:  Emerging Trends in HIV, NeuroAIDS,  Drug Abuse & EVs

Room 4

18:00 - 19:30

Satellite Symposium:  Research Methods for Extracellular RNA

Room 3

 Thursday, 3 May 2018 - ISEV Annual Meeting
07:30 - 20:00 Registration and Information Desk
08:00 - 09:00
 Networking Coffee

09:00 - 09:30

Welcome Remarks/Opening Ceremony

Special performance by tenor Sergi Gimenez Carreras

09:30 - 10:30

Plenary Session 1 - Autophagy, Metabolism and Aging

Room:  Auditorium

Session Chairs:  Juan Falcón-Pérez; Andrew Hill

09.30     Introduction and Lecture "The Mechanism and Regulation of Autophagy"     
              Dr.  Daniel Klionsky (University of Michigan, United States)
10.00     Introduction and Lecture "A Way Out When Selective Autophagy Fails in Aging"    
              Dr. Ana Maria Cuervo (Albert Einstein College of Medicine, United States)

10:30 - 10:45
Networking Coffee and Exhibits

10:45 - 12:15

Symposium Session 1: EVs in Metabolic Disorders 

Room: Auditorium

Session Chairs:  Juan Falcón-Pérez; Susmita Sahoo

Symposium Session 2: EVs and The Immune System

Room 5

Session Chairs:  Francesc Borrás; Esther Nolte-'t Hoen     

Symposium Session 3: EVs As Therapeutic Agents

Room 6

Session Chairs:  Yong Song Gho; Ewa Zuba Surma

 10:45 OT01.01  The bystander effect of aging - Ana O'Loghlen

OT02.01  Exosomal Transfer Of MicroRNAs During ImmuneSynapsis Contributes to The Fine-tuning of Immune Responses - Lola Fernandez Messina

OT03.01  Extracellular Vesicles Released by Mesenchymal Stem Cells Represent A Novel Therapeutic Option in Systemic Sclerosis - Daniele Noel

 11:00 OT01.02  Protective Effects of Caloric Restriction on Alzheimer's Disease Progression: Role  for Choroid Plexus Derived Extracellular Vesicles? - Charysse Vandendriessche OT02.02  Outside and Inside of Evs and Its Role in Phosphorylation of Interferon Regulatory Factor 3 - Elisa Lázaro-Ibáñez OT03.02  Neoadjuvant Chemotherapy Elicits A Pro-metastatic Cascade Through Evs and Monocytes - Ioanna Keklikoglou
 11:15 OT01.03  Diabetes Mellitus Drives Extracellular Vesicle Secretion and Promotes Increased  Internalization by Circulating Leukocytes -  Nicole Noren Hooten  OT02.03  Cigarette Smoke-exposed Monocyte-derived Dentritic Cells Release EVs That Elicit TH1/TH17 Responses in Autologous T-cells - Kenneth Witwer OT03.03  Shedding a Bevacizumab in Tumour Cells-derived Extracellular Vesicles as A New Therapeutic Resistance Mechanism in Glioblastoma - Thomas Simon
 11:30 OT01.04  Extracellular Vesicles in Type 1 Diabetes: Comparison of Immunological Properties of Divers Subpopulations Of Extracellular Vesicles of The Pancreatic Beta Cell secretome - Steffi Bosch  OT02.04  Mesenchymal Stromal Cell Extracellular Vesicles Modulate Innate and Adaptive Immune Cells at Multi-organ Level in a Model of Bronchopulmonary Dysplasia - Monica Reis OT03.04  Synergistic Effect of Extracellular Vesicles Loaded with Oncolytic Viruses and Paclitaxel for Cancer Drug Delivery - Mariangela Garofalo
 11:45 OT01.05  Higher Levels of Extracellular Vesicles in Type 1 Diabetes: A Cohort Study of 236 Patients - Sara Tehrani  OT02.05  Annexin a5(An5)-bound Extracellular Vesicles (EVs) From Mesenchymal Stromal Cells (MSCs) Show Enhanced and Specific Anti-inflammatory Effects - Maurizio Muraca OT03.05  Milk Exosomes - A Platform Nano-carrier for siRNA Delivery - Ramesh C. Gupta
 12:00 OT01.06  Characterization of The Exosomal Proteins And Their Potential As Regulators of Systemic Metabolism - Ruben Garcia Martin  OT02.06  Human Mesenchymal Stem Cells or Extracellular Vesicles Derived From These Cells Administered Intra-arterially modulate Immune Response in A Rat Model of Ischemic Brain Injury - Sylwia Dabrowska OT03.06  Bovine Milk-derived Extracellular Vesicles Can Inhibit Catabolic and Inflammatory Mediators In Articular Chondrocytes And Fibroblast-like Synoviocytes From Osteoarthritis Patients - Bartijn Pieters
12:15 - 13:30  Lunch/Exhibits/Posters
13:00 - 13:20 

Projection of 2D-3D Animation: Extracellular Vesicles - The Cell's Secret Messengers


Chair:  Dave Carter

13:30 - 15:00

Symposium Session 4: EVs as Cancer Biomarkers


Session Chairs: Takahiro Ochiya; Carla Oliveira

Symposium Session 5: EVs in Stem Cell and Cancer Growth
Room 5
Session Chairs:  Lorraine O'Driscoll; Peter Quesenberry
Symposium Session 6: EV Analysis By Microfluidics and Flow Cytometry   
Room 6
Session Chairs:  Jennifer Jones; Victor Ugaz
 13:30 OT04.01  EV Analysis of Clinical Urine Samples From Prostate Cancer Patients - Martin E. van Royen OT05.01  Oncogenic EGFR/Src signaling modulates the functionality of exosomal β4 integrin for tumor malignancy and organotropic metastasis - Tang-Long Shen OT06.01  Microfluidic Device Provides A Solution For A Time-course Analysis of EV Secretion - Takanori Ichiki 
 13:45 OT04.02  A Novel Strategy to Liquid Biopsy For Early Diagnosis of Lethal Prostate Cancer Employing Palmitoyl-proteomics of Extracellular Vesicles - Javier Mariscal

OT05.06  Increased hematopoietic extracellular RNAs and vesicles in the lung during allergic airway responses - Heather Pua

OT06.02  Rapid Quantification and Characterization of Individual Urinary EVs Using a Microfluidic Assay - Serhii Mytnyk
 14:00 OT04.03  Development of A Multiplex-To-Single Exosome Analysis (MT-SEA) Pipeline to Characterize Exosomes Associated With Tumor Progression and Responses to Treatment - Joshua Welsh OT05.03  Oral administration of bovine milk-derived extracellular vesicles reduce primary tumor burden but accelerate cancer metastases - Suresh Mathivanan OT06.03  Exosome Nanoarray For The Next Generation Single-exosome Analysis Platform - Kyohei Okubo
 14:15 OT04.04  Plasma Extracellular Vesicle Imaging by High Resolution Flow Cytometry in Patients Presenting for Diagnostic EUS-guided Pancreatic FNA - Terry K. Morgan OT05.04  3D culture of cancer cells in a polysaccharide-based hydrogel drastically alters the protein and RNA cargo of EVs - Christopher Millan OT06.04  Hollow Organosilica Beads As Reference Particles For Optical Detection Of Extracellular Vesicles - Zoltan Varga 
 14:30 OT04.05  Exosomes and Microvesicles Contain More Tumor RNA Than Platelets - Kay Brinkmann OT05.04  lncRNA 19 from human adipose stem cells derived exosomes promote the regeneration of hepatocytes by up-regulating HGF/c-Met pathway and significantly improve survival of rats with acute liver failure - Yinpeng Jin OT06.05  Bioengineered Nanovesicles As Extracellular Vesicle-Mimetics: A Novel Standard For Extracellular Vesicle Analysis - Estefania Lozano-Andres 
 14:45 OT04.06  Clinical Relevance Of The Defining The Most Abundant Fraction of Mutated Oncogenic DNA and RNA Among Different EV Subtypes - Irina Nazarenko

OT05.02  The role of large oncosomes in leukaemia -Valentina R. Minciacchi

OT06.06  Isolation of Microvesicles And Exosomes By Fluorescence-triggered FACS - Alain Brisson
15:00 - 15:30 Networking Coffee with Exhibitors
15:30 - 16:30

Session 7 - Oral with Poster 1: EV Functional Studies In Different Models

Room: Auditorium

Session Chair:  Hernando del Portillo

Session 8 - Oral with Poster: EV Biomarkers and Subpopulations

Room 5

Session Chair:  Francesc Borrás

Session 9 - Oral with Poster 3: Biogenesis, Signaling & Characterization

Room 6

Session Chair:  Maria Yañez-Mó

 15:30 OWP1.01  Immunomodulatory Function Of Human Mesenchymal Stromal Cells-derived Extracellular Vesicles on Type-I Interferon Response In Human Plasmacytoid Dendritic Cells And Lupus Murine pDCs - Lin Kui  OWP2.01  Isolation And Phenotype Characterization of Microvesicle Subpopulations From Mixed Cells in an in vitro Model of Lung Microvascular Injury - Nikhil Tirlapur 
OWP3.01  Sarco/Endoplasmic Reticulum ATPase Inhibition Activates Calcium Signaling Pathways For Microvesicle Biogenesis - Jack D. Taylor 
 15:35 OWP1.02  Role of CD44 in Therapeutic Mesenchymal Stem Cell-derived Extracellular Vesicles For Joint Diseases - Enrico Ragni  OWP2.02  Detection and Characterization of Different Neuronal and Glial Populations of Exosomes By Surface Plasmon Resonance Imaging - Alice Gualerzi OWP3.02  Origin of Extracellular Vesicles Released During Exhaustive Exercise - Alexandra Brahmer 
 15:40 OWP1.03  Osteoblast-secreted Extracellular Vesicles Stimulate The Expansion of CD34+ Human Umbilical Cord Blood Cells - Jess Morhayim  OWP2.03  Microscale Electrophoretic Separations of Exosomes - Yuliya Shakalisava  OWP3.03  Extracellular Vesicles As Mediators of Periphery-to-brain Communication In Inflammation Associated Brain Disorders - Nagiua Haymour 
 15:45 OWP1.04  Prostate Cancer-derived Extracellular Vesicles Facilitate Osteoclast Fusion And Differentiation Via Enhancing Filopodia Formation in Osteoclast Precursors - Fumihiko Urabe  OWP2.04  Normalization of Urinary Extracellular Vesicles - Charles J. Blijdorp  OWP3.04  Extracellular Vesicles Deformation On Surface: Some Tracks To Limit It - Ksenia Maximova 
 15:50 OWP1.05  Investigating The Roles of Macrophage Colony-Stimulating Factor (CSF-1) And Carbonic Anhydrase 9 (CAIX) In Neratinib Resistant HER2+ Breast Cancer Cell Lines and Extracellular Vesicles - Michelle C. Lowry  OWP2.05  Comparative Analysis of Raman Signals Between Non-small Cell Lung Cancer (NSCLC) Cell-derived Exosomes and Their Potential Protein Markers - Hyunku Shin  OWP3.05  Comparison Of Generic Fluorescent Dyes for Detection of Extracellular Vesicles By Flow Cytometry - Leonie de Rond 
 15:55 OWP1.06  Extracellular vesicles isolated from cardiosphere-derived cells and mesenchymal stem cells elicit distinct immunomodulatory properties in vitro and in vivo - Geoffrey de Couto OWP2.06  Development of High Sensitivity Flow Cytometry for Sizing and Molecular Profiling of Individual Extracellular Vesicles Down to 40 nm - Xiaomei Yan OWP3.06  Role of calcium signaling in the biogenesis of different types of extracellular vesicles derived from the same cell - Ákos Lőrincz
 16:00 OWP1.07  Role of Wnt4 exosomes in thymic aging - Krisztina Banfai OWP2.07  Immunofluorescence Flow Cytometry of Extracellular Vesicle Surface Proteins - John Nolan OWP3.07  Unraveling the distribution of extracellular vesicles in vivo using recombinant tetraspanins - Stefan Vogt
16:05 OWP1.08  Impact of pathogenic microbes and healthy microbiota by Lactobacillus-derived extracellular vesicles - Bao-Hong Lee OWP2.08  Free flow electrophoresis allows preparation of extracellular vesicles fractions with high recovery and purity rates - Christian Reiter OWP3.08  Evidence for selective mRNA sorting into cancer exosomes - Mohammad Arshad.Aziz
16:10 OWP1.09  Catching the Hedgehog: Unraveling Hedgehog secretion during filopodia-mediated transport - Gustavo Aguilar OWP2.09  Isolation of extracellular vesicle-associated small RNA from canine mitral valve interstitial cells using ultracentrifugation and tangential flow filtration with size exclusion chromatography - Vicky Yang OWP3.09  Alterations in the miRNA cargo of HIV-infected macrophage-derived extracellular vesicles promote pulmonary smooth muscle proliferation - Navneet K. Dhillon
16:30 - 17:15

The EV Blood Roadmap

Room:  Auditorium

-Welcome - Chris Gardiner

-Introduction - Rienk Nieuwland

-Biospecimen - Aled Clayton

-Pre-analytical Variables - Kenneth Witwer

-EV TRACK - An Hendrix

-Plenary Discussion - All Speakers

Meet the Journal Editors

Room 5

Session Chairs:  Hector Peinado; Marca Wauben

-Nature Communications - Simona Fiorani, Team Manager and Senior Editor

-PLOS|Biology - Ines Alvarez-Garcia, Senior Editor

-Science Matters - Lawrence Rajendran, Founder and Chief Executive Officer

-Journal of Extracellular Vesicles - Peter J. Quesenberry, Co-editor in Chief


17:15 - 18:30

Poster Session 1 (PT):
PT01: EVs, Pathogens and Cross-organism Communication (Parasitic Infections)
PT02: EVs in Reproduction and Pregnancy
PT04: Tumor-stroma Interactions by EVs 
PT05: EVs as Cancer Biomarkers-proteomics
PT06: EVs in Cellular Differentiation and Organ Development
PT07: EV-inspired Therapeutics, Vaccines, and Clinical Trials
PT08: Cardiovascular Insult
PT09: EVs in Autoimmunity and Sepsis
LBT01: Methodology
LBT02: Cancer I

18:30 - 20:00 

Meet the Expert Session: RNA And EVs: The What, Why and Where of their Interactions

Room:  Auditorium

Session Chair:  Andrew Hill

Meet the Expert Session: Regulatory Aspects of EVs to Reach the Clinic

Room 5

Session Chair:  Susmita Sahoo

Meet the National Societies and Outreach Strategies

Room 6

Session Chair:  Isabel Guerrero


RNA in Liquid Biopsies - Louise Laurent

Manufacturing License vs. Market Authorization - Crossroads for Therapeutic EV Development - Mario Gimona
18:50 Exploring the Small RNA World of Extracellular Vesicles - Esther Nolte-'t Hoen Exosomes Vaccines in Veterinary: A Challenge - Lorenzo Fraile
19:10 Functional Aspects of Small RNAs in EVs Related with Aging - Johannes Grillari Regulatory Aspects of EVs to Reach the Clinic - Xavier Lluria
    Extracellular Vesicles as Medicinal Product: An Evolving Regulatory Perspective - Rosaria Giordano

Friday, 4 May 2018 

07:30 - 20:00  Registration and Information Desk
08:30 - 10:00 

Symposium Session 10 - EV Biogenesis and Update


Session Chairs:  Isabel Guerrero; Guillaume van Niel

Symposium Session 11- EVs and Metastatic Niches                                                                                                        Room 5

Session Chairs:  Jacky Goetz; Vincenza Dolo

Symposium Session 12 - EV Characterization: State-of-the-Art Approaches

Room 6

Session Chairs:  Irina Nazarenko; Rienk Nieuwland

08:30 OF10.01  Following the Trafficking of Extracellular Vesicles Markers to Understand the Biogenesis of Different Extracellular Vesicles Subtypes - Mathilde Mathieu OF11.01  Breast Cancer-derived Extracellular Vesicles Modulate The Activity of Signaling Pathways in The Brain Microenvironment - Golnaz Morad OF12.01 Gold Nanoparticle Ring And Hole Structures-based Platforms For Capture and Label-free Detection of Exosomes - Duraichelvan Raju 
08:45 OF10.02  A Novel Conserved Exosome Biogenesis Pathway Mediates Adaptive Response to Microenvironmental Stress in Cancer Cells - Deborah Goberdhan OF11.02  Zebrabow as in vivo Model System To Monitor Vesicles Mediated Transfer In Cancer - Martin E. van Royen OF12.02  Vibrational Spectroscopy as a Tool for Fingerprinting Tumor Exosomes - Randy Carney 
09:00 OF10.03  HA-EVs Are a Unique Species of EV With Diverse Properties and Widespread Biological Relevance - Kirsi Rilla OF11.03  Pre-metastatic Cancer Exosomes Induce Immune Surveillance By Patrolling Monocytes - Olga Volpert OF12.03  "None of us is the same as all of us": Nanoscale Probing of Heterogeneity of Stem-cell Derived Extracellular Vesicles by Resonance Enhanced Atomic Force Microscope Infrared Spectroscopy - Wojciech Chrzanowski 
09:15 OF10.04  The Integrin Mac1/CR3 Plays a Central Role in Production and Cargo Editing of EVs Issued From Neutrophilic Granulocytes - Erzsébet Ligeti OF11.04  Melanoma-derived Exosomes Reinforce Metastasis By Inducing Lymphangiogenesis and Impairing Dendritic Cell Function - Hector Peinado  OF12.04  Membrane Protein Quantification On Extracellular Vesicles By Surface Plasmon Resonance Imaging and Time-resolved Fluorescence Immunoassay - Frank A.W. Coumans
09:30 OF10.05  Extracellular Vesicle Budding is Inhibited by Redundant Regulators of TAT-5 Flippase Localization and Phospholipid Asymmetry - Ann M. Wehman OF11.05  Paracrine Mechanisms Induced By Large Oncosomes Spontaneously Shed By Aggressive Cells to Promote Adhesion and Invasion of Prostate cancer via an integrin-dependent Activation of FAK-AKT Pathway - Chiara Ciardiello OF12.05  Proximity Assays For Detection and Characterization of Exosomes - Masood Kamali-Moghaddam 
09:45 OF10.06  Uptake of Extracellular Vesicles in a Cell Free Extract - Gregory Lavieu OF11.06  Circulating Large EVs in Plasma of Patients With Metastatic Prostate Cancer Contain Chromosomal DNA and Report Cancer-specific Genomic Alterations-Dolores Di Vizio OF12.06   Individual EV Visualization Using TIRF Microscopy for EV Subpopulation Study - Chungmin Han 
10:00 - 10:30 Networking Coffee with Exhibitors
10:30 - 11:45
Plenary Session 2 - Advances in Exosomes Biology 
Session Chairs:  Antonio Marcilla; Marca Wauben
10:30  Introduction and Lecture "Mechanism of Small RNA Sorting into Exosomes Secreted by Cultured Human Cells"
 Dr. Randy Schekman (University of California - Berkeley, United States)
11:00  Introduction and Lecture "Advances on the Cell Biology of Extracellular Vesicles"
 Dr. Graça Raposo (CNRS Institut Curie, France)
11:45- 12:20 

Featured Abstracts Friday

Session Chair:  Clotilde Théry

 11:45 Introduction
11:50 FA1.01  Effect of Tetraspanin-blocking Peptides in the Biogenesis of Exosomes in Melanoma Cells - Carla Mazzeo
12:05 FA1.02  Mechanisms For The Exosomal Secretion and Transmission of a-synuclein in the Brain - Jason Howitt
12:20 - 13:45   Lunch with Poster Viewing
12:40 - 13:45 

Young Career Development on Academy and Industry in the Field of Extracellular Vesicles

Room 3

Session Chair:  Delphine Muriaux

12:40 - 13:45 

ISEV ISAC ISTH EV Flow Cytometry Work Group

Room 4

Session Chair:  Marca Wauben and Rienk Nieuwland

12:40  Development of high sensitivity flow cytometry for sizing and molecular profiling of individual extracellular vesicles down to 40 nm - Xiaomei Yan

12:55  Scatter-based reference materials - Josh Welsh

13:10  Fluorescence-based reference materials - John Nolan

13:25  Towards implementation of reporting guidelines for EV flow - Joanne Lannigan

13:35  New standarization study for scatter-based EV-concentration measurements - Frank Coumans

13:40  Next steps - Discussion Moderators:  Marca Wauben, Rienk Nieuwland


13:45 - 15:15 

Symposium Session 13 - Role of Tumor EVs in Cell-Cell Communication 


Session Chairs:  Antonella Bongiovanni; Hector Peinado

Symposium Session 14 - Tissue Injury and Repair

Room 5

Session Chairs:  Bernd Giebel; Mariko Ikuo

Symposium Session 15 - EVs and the Nervous System

Room 6

Session Chairs:  Andrew Hill; David Otaegui

13:45 OF13.01  Computer guided image analysis of nuclear membrane instability in tissues reveals clinical relevance for nucleus-derived EVs - Andries Zijlstra OF14.01  Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model Of Ischemic Stroke - Robin Webb  OS15.01  Study of exosomal microRNAs from microglia involved in neuroprotection in Hirudo medicinalis - Quentin Lemaire
14:00 OF13.02  3D Culture Modelling Illustrates A Role For EVs in Mediating The Biomechanics of The Tumour Microenvironment - Nicholas Peake  OF14.02  Hypoxia Modifies The Release of Extracellular Vesicles By Mesenchymal Cells Improving Renal Recovery After Ischemia-reperfusion Injury - Rafael S. Lindoso  OF15.02  Extracellular Vesicle Associated microRNA-29a Elicits Microglial Inflammation And Synaptodendritic Injury During Chronic Methamphetamine Abuse - Sowmya V. Yelamanchili 
14:15 OF13.03  Melanoma-derived Microvesicles are Taken Up By Lymph Node Resident Macrophages and Lymphatic Endothelial cells and Induce Lymph Node Remodeling - Lothar Dieterich  OF14.03 Human Induced Pluripotent Stem Cell Extracellular Vesicles Trigger A MiRNA-dependent Anti-inflammatory Mechanism To Tackle Ischemia - Mario Barilani  OF15.03  Apolipoprotein E4 Compromises Brain Exosome Production And Secretion - Katherine Y. Peng 
14:30 OF13.04  GD3 Ganglioside-Enriched Extracellular Vesicles Stimulate Melanocyte Migration - Andreia H. Otake  OF14.04  Exosomal miR-29 Mediates The Therapuetic Effects of Placenta-derived Mesenchymal Stromal Cells In Duchenne Muscular Dystrophy - Chaya Brodie  OF15.04  Conditional Deletion of Rab35 and Alix in Mice To Study Exosomes in Neuron-glia Interaction in vivo - Kerstin Miebach 
14:45 OF13.05  Exosomal Heparan Sulphate Proteoglycans (HSPGs) Drive Induction of A Pro-angiogenic Stromal Cell Phenotype - Alex P. Shephard  OF14.05  Molecular Content And Regenerative Potential Of EVs From Native And Genetically Modified Induced Pluripotent Stem Cells In Heart Repair in vivo - Ewa K. Zuba-Surma  OF15.05  Interrelationships Between Endosomal Pathology and Exosomal Generation and Release In Neurodegenerative Disorders - Efrat Levy 
15:00 OF13.06  CD44 Is a Novel Homing Receptor For Extravellular Vesicles - Kai Harkonen  OF14.06  Opiod-mediated Extracellular Vesicle Production And NLRP3 Inflammasome Activation Cause Vascular Damage - Stephen R. Thom  OF15.06  Immunomodulatory Treatment Approach To CNS Injury: Role of Mesenchymal Stem Cell Derived Extracellular Vesicles - Amit K. Srivastava 
15:15 - 15:45 Networking Coffee with Exhibitors
15:45 - 16:45

Symposium Session 16 - Strategies For Studying Blood-related EVs


Session Chairs:  Edit Buzás; Chris Gardiner

Symposium Session 17 - Alterations In EV Stability And Function

Room 5

Session Chairs:   Carmen Fernandez; Ana Claudia Torrecilhas 

Symposium Session  18 - EV-inspired Therapeutics In Veterinary Medicine 

Room 6

Session Chairs:  Marca Wauben; Hanne Winther Larsen

15:45 OF16.01  Rapid Isolation Of Artifical Liposomes and Exosomes Extracted From Plasma of Healthy Donors Utilizing A Novel Insulator-based Dielectrophoretic Device - Leyla Esfandiari OF17.01  Overexpression of miR-504 in Glioma Stem Cells Inhibits The Oncogenic Potential And The Crosstalk Of These Cells With Microglia Via Exosomal Delivery - Chaya Brodie OF18.01  Targeted-pig Trial on Safety and Immunogenicity of Serum-derived Exosomes Obtained From Porcine Respiratory And Reproductive Virus Infections - Sergio R. Montaner Tarbes 
16:00 OF16.02  Release of Mitophagosomes From TRAP-activated Platelets - Silvia H. De Paoli  OF17.02  Pathogen-derived Extracellular Vesicles Mediate Division of Labour virulence in Fatal Human Fungus Cryptococcus Gattii - Ewa Bielska OF18.02  ARMMs as a versatile platform for intracellular delivery of macromolecules - Quan Lu 
16:15 OF16.03  What Are We Looking At? Extracellular Vesicles, Lipoproteins, or Both? - Jens B. Simonson  OF17.03  The Role Of Extracellular Vesicles In Mediating Radiation-induced Bystander Effects in The Haematopoietic System - Katalin Lumniczky  OF18.03  Chitosan Coated Extracellular Vesicles As An Adjuvant For immunization Against Salmonid Rickettsial Septicemia In An Adult Zebrafish Model - Julia Tandberg 
16:30 OF16.04  Acetylcholinesterase Activity Co-isolates Minimally With Small EVs and Does Not Correlate With Particle Count - Dillon C. Muth  OF17.04  The RNA-binding Protein hnRNPA2B1 Inhibits the Export of miR-503 Into Exosomes - Jennifer Perez Boza  OF18.04  Level of Extracellular Vesicles, Carrying The Fibrinolytic Activator tPA, is Reduced in Coronary Venous Blood During Stimulation of Cardiac Sympathetic Nerves in Pigs - Trude Aspelin 
16:45 - 17:15

Industry Sessions


Session Chair:  Hector Peinado

 16:45  Beckman Coulter Life Sciences
 17:00  Particle Metrix
17:15 - 18:30   Poster Session 2 (Friday):
PF01: Analysis of EVs in Liquid Biopsy (Storage, Preparative Studies, Spike-ins, etc)
PF02: EVs in Cancer: Surrogate Marker
PF03: EVs and Stem Cells (Including Cancer)
PF04: EVs and the Immune System
PF05: EV-based Non-cancer Biomarkers
PF06: Novel Developments in EV Isolation
PF07: EVs in Diseases of the Nervous System
PF08: EVs in Cardiovascular Diseases and Coagulation
PF09: EVs, Pathogens and Cross Organism Communication
LBF04:  Pathogens
LBF06:  Neurobiology

18:30 - 20:00

Meet the Expert Session: in vivo Imaging on EVs


Session Chair:  Hector Peinado

Meet the Expert Session:  EVs on Immunology and Vaccines

Room 5

Session Chair: Mar Vales

Meet the Expert Session:  Biobanks on EVs

Room 6

Session Chair:  Juan Falcón-Pérez

 18:30 Tracking Tumor Extracellular Vesicles in vivo at High Spatio-temporal Resolution - Jacky Goetz Studying Immunity to EVs: In Vitro versus In Vivo - Susanne Gabrielsson The Importance of Reference Controls for EVs Characterization: Role of Biobanks - Jose Antonio Lopez

Current Methods to Study the in vivo Actions of Cancer EVs - Michiel Pegtel

Plasma-derived Exosomes in Cancer as Potential Biomarkers of Disease Progression and Immune Competence - Theresa I. Whiteside Applicability of Extracellular Vesicles for Biobank Research - Maija Pukha

Exovesicles as Carriers of the Morphogenetic Hedgehog Signal during Epithelial Development - Isabel Guerrero

EV-secreted and Non-secreted alpha-Gal Glycotopes as Vaccine and Biomarkers for Chagas Disease - Igor C. Almeida Doing a Bio-bank Job and Getting Away with It! - Ryan Pink
 19:30 Intravital Imaging of Extracellular Vesicle Exchange in Cancer - Anoek Zomer Common and Specific Effects of EV Subtypes in Immune Responses, Consequences for Vaccine Application - Clotilde Théry Sample Collection for Successful Exosome Based Diagnostics - Johan Skog

Saturday, 5 May 2018 

07:30 - 20:00 Registration and Information Desk 
08:30 - 10:00

Symposium Session 19 - Cross-organism Communication In Bacterial Infections


Session Chairs:  Igor Almeida; Cherie Blenkiron

Symposium Session 20 - EVs as Shuttles Of Genetic Material

Room 5

Session Chairs:  Kwang Pyo Kim; Kenneth Witwer

Symposium Session 21 - Role of EVs in Regulating Tumor Cell Behavior 

Room 6

Session Chairs:  Susanne Gabrielsson; Jason Webber 

08:30 OS19.01  Transcytosis Of Extracellular Vesicles Produced By Bacillus Subtilis 168 in Human Intestinal Caco-2 Cell Monolayers - Ana Paula Dominguez OS20.01  Systematic evaluation of techniques for the isolation and detection of small non-coding RNA from urine-derived extracellular vesicles - Elena S. Martens-Uzunova  OS21.01  IncRNA HOTAIR Affects EMT And Extracellular Vesicle Content and Function - Carla J. Beckham
08:45 OF19.02  Explosive Cell Lysis Is Required For Membrane Vesicle Biogenesis in Pseudomonas Aeruginosa Biofilms - Cynthia B. Whitchurch  OS20.02  Extracellular Vesicles Mediate The Horizontal Transfer Of An Active LINE-1 Retrotransposons - Yumi Kawamura  OS21.02 RASSF1C Oncogene Promotes Amoeboid Phenotype and Invasiveness Via Extracellular Vesicle Transfer In Breast Cancer - Maria Laura Tognoli 
09:00 OF19.03  Extracellular Vesicles Secreted by Bacteria Induce Host Cell Apoptosis - Pankaj Deo  OS20.03  Diverse Long-RNAs Are Differentially Sorted Into Exosomes Secreted By Mutant KRAS Colorectal Cancer Cells - Jessica Abner  OS21.03  Role Of Exosomes In Controlling Directional Migration Of Cancer Cells - Alissa Weaver 
09:15 OS19.04  Nasal Microbiota Modifies The Effects Of Particulate Air Pollution On Plasma Extracellular Vesicles - Jacopo Mariani  OS20.04  Extracellular Vesicles Limit Invasive Potential of Fibroblasts In An Autocrine Mechanism Mediated By EVs MicroRNA - Paulina Podszywalow-Bartnicka OS21.04  Hypoxia-driven Changes in EV Composition Are Autography-dependent - Marijke I. Zonneveld 
09:30 OS19.05  Amplifying Host Innate Immunity Through Modulation of p38, Jak2, and ALK Activities and Induction of Macrophage Differentiation and IL-6 Dependent Bacterial Clearance By  Exosomes Released From Yersinia Pestis-infected Monocytes - Ramin M. Hakami  OS20.05  The Impact of 3D Cellular Architecture in The MicroRNA and Protein Content Of Extracellular Vesicles - Sara Rocha  OS21.05  Extracellular Vesicles From Fibroblasts Undergoing Oncogene Induced Senescence Are Enriched In Lysophosphatidic Acid - Krizia Sagini 
09:45 OS19.06  P2X1 Purinergic Blockade Protects Cells From Microvesicles Release and  Shiga Toxin-mediated Toxicity - Karl Johansson  OS20.06  Integrative Pathway Analysis On Protein and miRNA Allows Investigation of the Role of Extracellular Vesicles in Mediating the Adaptive Response of Prostate Cancer Cells To Androgen Deprivation - Carolina Soekmadji OS201.06  Extracellular Vesicles Transfer of The Myddosome As The Proimflammatory Signal From The Waldenstrom Macroglobulinaemia Lymphoma Cells Carrying MyD88L265P Mutation - Mateja Mancek Keber 
10:00 - 10:30   Networking Coffee with Exhibitors
10:30 - 11:00

Plenary Session 3 - EVs in Environment, Diet and Health


Session Chairs:  Hernando del Portillo; Kenneth Witwer

10:30     Introduction and Lecture "Parasitic Worm EVs: From Vaccines to Anti-inflammatories"
              Dr. Alex Loukas (Australian Institute of Tropical Health and Medicine, Australia)

11:00 - 11:35

Featured Abstract Saturday


Session Chair:  Ramaroson Andriantsitohaina

 11:00  Introduction
 11:05  FA2.03  Live Tracking of Endogenous Exosomes in vivo - Frederik Verweij
 11:20  FA2.04  Spatio-temporal Analysis of Glia to Neuron Exosome Transfer in vivo Using CreERT2-reporter Transgenic Mouse Models - Eva Maria Kramer-Albers
11:35 - 12:30 

ISEV General Assembly


 12:30 - 13:45 Lunch with Poster Viewing
 13:45 - 15:15

Symposium Session 22 - Parasitic EVs: From Basics to Translation


Session Chairs:  Amy Buck; Neta Regev-Rudzki

Symposium Session 23 - Mechanisms of EV Uptake and Biodistribution

Room 5

Session Chairs:  Dave Carter; Maria Yañez-Mó

Symposium Session 24 - EV-inspired Therapeutics

Room 6

Session Chairs:  Nobuyoshi Kosaka; Hubert Yin

13:45 OS22.01  Understanding Host: Pathogen Interactions Mediated By Exosomes Produced By The Parasite Trichomonas Vaginalis - Patricia J. Johnson  OS23.01  Casting a Line To Trailing Cells: A Simple Mechanism For Polarizing Signaling In The Posterior Lateral Line Primordium - Damian E. Dalle Nogare  OS24.01  Dynamic Bioreactor Systems For Clinical Scale Production Of Human Amnion Epithelial Cells-derived Extracellular Vesicles - Gina D. Kusuma 
14:00 OS22.02  The Role Of Extracellular Vesicles In The Modulation of Endothelial Junctions In an in vitro Model of Cerebral Malaria - Valery Combes   OS23.02  Exploring The Role Of Exosomal Surface Glycans In Cellular Uptake - Charles Williams  OS24.02  Development of Intracellular Delivery System Bases on Extracellular Vesicles Derived From Cells in Acidic Environments - Ikuhiko Nakase
14:15 OS22.03  Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite-host cross talk - Peter Nejsum OS23.03  a5B1 Integrinregulates Cell Adhesion To Tumoral Exosomes - Beatriz Cardenes  OS24.03  Towards Extracellular Vesicles As Versatile Biogenic Drug Delivery System: Loading Method By Facilitated Fusion with Liposomes Of Tunable Membrane And Inner Composition - Max Piffoux 
 14:30 OS22.04  Discovery of P. Vivax Proteins In Plasma Derived Exosomes From Malaria-infeced Liver-chimeric (huHep) FRG Mice - Melisa Gualdrón-Lopez  OS23.04  A system of cytokines encapsuated in extracellular vesicles - Leonid Margolis OS24.04  Allogenicity Boosts Exosome-Induced Antigen-specific Mumoral and Cellular Immunity and Mediate Long-term Memory in Vivo - Susanne Gabrielsson
14:45 OS22 05  Development Of Human Reticulocyte-derived Exosomes As A New Vaccine Delivery Platform Against Plasmodium Vivax Malaria - Miriam Diaz-Varela OS23.05  Plug-and-play Decoration Of Isolated EVs With Nanobodies Improves Their Cell-specific Interactions - Sander A.A. Kooijmans  OS24.05  RNA Nanoparticle Orientation To Control Ligand Display On Exosomes For Cancer Regression - Daniel W. Binzel 
15:00 OS22 06  Secreted Extracellular Vesicles From The Hookworm-like Nematode Nippostrongylus Brasiliensis Prevents Inducible Colitis In Mice - Ramon M. Eichenberger 
OS23.06  TGF Beta-1 On Extracellular Vesicle Surface: Scratching the Surface For Orientation, Origin and Function - Ganesh V. Shelke  OS24.06  Mesenchymal Stem Cell-derived Extracellular Vesicles Delivered In A Thermosensitive Gel Are Effectibe Healing Mediators In Porcine and Murine Models Of Digestive Fistula - Max Piffoux
15:15 - 15:45  Networking Coffee with Exhibitors
 15:45- 17:15

Symposium Session 25 - EVs and Viral Infections   


Session Chairs:  Leonid Margolis; Alissa Weaver

Symposium Session 26 - EV-based Non-cancer Biomarkers

Room 5

Session Chairs:  Carolina Sokemadji; Hidetoshi Tahara

Symposium Session 27 - OMIC Applied to EVs

Room 6

Session Chairs:  Alicia Llorente, Suresh Mathivanan

 15:45 OS25 01  Human Immunodeficiency Virus Tat-mediated Synaptic Alterations- Platelet Derived Growth Factor as a Therapeutic Strategy - Shilpa Buch  OS26 01  Extracellular Vesicle Biomarkers Predict Response To Experimental Treatment In a Clinical Trial in Parkinson’s Disease - Dimitrios Kapogiannis  OS27 01  A systems biology approach on pericardial fluid exosomes unravels relationships between miRs, proteins and metabolites that may play a potential role in promoting heart ischemia in diabetic patients - Costanza Emanueli 
16:00 OS25 02  Exosomal Release of the Human Cytomegalovirus-encoded Chemokine Receptor US28 - Maarten P. Bebelman OS26 02  Validation of Human Cerebrospinal Fluid microRNAs as Biomarkers For Alzheimer's Disease - Julie Saugstad OS27 02  Quantitative Proteomics of Transforming Growth Factor Beta Receptor Type 2- Primed Exosomes Derived From DNA Mismatch Repair-deficient Colorectal Tumor Cells - Fabia Fricke 
 16:15 OS25 03  JC Polyomavirus Uses Extracellular Vesicles to Infect Target Cells - Jenna Morris-Love  OS26 03  Identification of microRNAs From Extracellular Vesicles as Potential Biomarkers For Frontotemporal Dementia - Laura Cervera-Carles  OS27 03  Proteomic Signature of Circulating Extracellular Vesicles in Dilated Cardiomyopathy - Ana Gámez-Valero
 16:30 OS25 04  Extracellular Vesicles Released by Zika Infected Cells Carry Viral Components: Implications For Viral Dissemination And Pathogenesis - Armando Menezes-Neto

OS26 04  On-Chip Detection, Sizing And Proteomics Of Extracellular Vesicles - Celine Elie-caille

OS27 04  Tracking and Capturing of Bioorthogonal Labeled RNA Carried by Extracellular Vesicles During Maternal-embryo Communication - Masoumeh Es-haghi 
16:45 OS25 05  Microglia Respond to HIV-1 Protein Nef Expression By Releasing Distinct Extracellular Vesicle population - Metka Lenassi OS26 05  Circulating Macrophage-Derived Extracellular Vesicles Predict Post-Operative Myocardial Infarction - Wade T. Rogers OS27 05  M. Tuberculosis Immunomodulatory Lipids, Beyond The Wall. Global Lipidomic Analysis of Vesicles Released by the Bacillus and by Infected Host Cells - Emilie Layre
 17:00 OS25 06  Identifying Novel Cellular Components Specifically Incorporated Into HIV Versus Exosomes and Other Small EVs - Lorena Martin-Jaular  OS26 06  Mass Spectrometry Analysis of Urinary Extracellular Vesicles Recovered in the Low Centrifugation Pellet After Elimination of Uromodulin By Tris (2-carboxyethyl) Phosphine Hydrochloride - Luca Musante  OS27 06  ExRNA Atlas Analysis Provides An exRNA Census And Reveals Six Types of Vesicular and Non-vesicular exRNA Carrier Profiles Detectable Across Human Body Fluids - Oscar D. Murillo 
17:15 - 18:30  Poster Session 3 (Saturday):
PS01: EVs in Tissue Injury and Repair
PS02: EV Engineering and Sorting of Cargo in EVs
PS03: EV Biogenesis and Uptake
PS04: Novel Developments in EV Isolation
PS05: EVs in the Nervous System (Neuronal Network, Blood-Brain-Barrier)
PS06: EVs in Metabolic Diseases and Aging
PS07: EVs in Tumor Metastasis
PS08: EVs as Cancer Biomarkers
PS09: Novel Developments in EV Characterization
LBS07:  Repair and Signalling
LBS08:  Biogenesis
LBS09:  Cancer II
18:30 - 20:00

Meet the Expert Session - Biomarkers on EVs


Session Chair:  Andrew Hill

Meet the Expert Session - EVs in Neglected Tropical Diseases

Room 5

Session Chairs: Igor C. Almeida; Carmen Fernandez-Becerra

Meet the Expert Session - Can Research on EVs Accelerate Clinical Impact in Leukemia?           
(Supported by the Fundació Josep Carreras)

Room 6

Session Chairs:  Evaristo Feliu Frasnedo; Theresa I. Whiteside

18:30 EVs Biomarkers Discovery and Detection Strategy - Lei Zheng EVs in Flatworm Infections - Antonio Marcilla Cell-cell Communication between Immune and Tumor Cells. Implications for Tumor Cell Resistance Mechanisms - Beatriz Martin Antonio
 18:50 EV-mediated Biomarkers for Early Detection of Cancer - Takahiro Ochiya EVs and exRNA in Parasitic Nematodes: At the Host Interface - Amy Buck Leukemia Exosomes and their Role in Defining Tumor Microenvironment - Stefania Raimondo
 19:10 EV-related Biomarkers in Peritoneal Dialysis - Francesc Borrás Extracellular Vesicles in Protozoa Infection - Ana Claudia Torrecilhas

Leukemia EVs: Impact on Early Hematopoiesis and Diagnostic Potentials - Bernd Geibel


Searching for Prostate Cancer Biomarkers in Urinary Exosomes - Alicia Llorente

Non-Enveloped LRV1 Virus Exploits the Leishmania Exosomal Pathway for its Propagation - Martin Olivier

Yin and Yang of Extracellular Vesicles in Leukemia - Peter Quesenberry

 Sunday, 6 May 2018

08:00 - 14:00 Registration and Information Desk 
09:00 - 10:00

Symposium Session 28 - Late Breaking Abstracts


Session Chair:  Dolores Di Vizio

Symposium Session 29 - Late Breaking Abstract

Room 5

Session Chair:  Tang Long Shen

Symposium Session 30 - Late Breaking Abstracts

Room 6

Session Chair:  Lei Zheng

 09:00 LBO1.01  Blood microvesicles derived from neurovascular network correlate with amyloid-β deposition in the brains of postmenopausal women - Muthuvel Jayachandran LBO2.01  On-chip liquid biopsy: Progress in isolation of exosomes and their RNA sequencing for prognosis of prostate cancer - Navneet Dogra LBO3.01  Regulation of exosome secretion via the intricate tuning of multivesicular endosome transport towards the plasma membrane - Guillaume van Niel
09:15 LBO1.02  Graphene-oxide quenching-based molecular beacon imaging for exosome-mediated transfer of neurogenic miRNA on microfluidic platform - Hyun Jeong Oh LBO2.02  Tissue-tropism, parasite cargo and signaling of spleen fibroblasts by plasma-derived exosomes from vivax malaria infections - Haruka Toda LBO3.02  Naturally and targeted engineered DNA cargo in bacterial extracellular vesicles control rates of interspecies horizontal gene exchange and can be regulated by environmental cues - Frances Tran
09:30 LBO1.03  Menadione driven oxidative stress related microvesicle shedding associates with resilience to hypoxia in a neuronal ischaemia model - Emma Buzzard LBO2.03  Alterations in platelet membranes and formation of lipid mediators during storage - Sami Valkonen LBO3.03  Harnessing extracellular vesicles from human red blood cells for gene therapies against cancer - Minh TN Le
09:45 LBO1.04  Unravelling the role of extracellular small heat shock proteins in neuroinflammation - Joy Irobi LBO.04  Validation of purification methods for extracellular vesicles - Jacopo Zini LBO3.04  Exosomes as drug delivery vehicles for therapeutic proteins to the brain - Elena V Batrakova
10:00 - 10:30  Networking Coffee with Exhibitors
10:30 - 11:00

Plenary Session 4 - Tissue Microenvironment and Architecture                                                       


Session Chairs:  Eva Maria Kramer-Albers; Hector Peinado

Introduction and Lecture "How does a Linear Sequence of DNA Become a 3-dimensional Tissue and Why Cancer Cells Forget!"
Dr. Mina Bissell (Lawrence Berkeley Laboratory, United States)

11:00 - 12:30

Featured Abstracts Sunday


Session Chair:  Rienk Nieuwland

 11:00 Introduction
 11:15 FA3.01  Recombinant Extracellular Vesicles: Biological Reference Material to Standardize Extracellular Vesicle Research - Edward Geeurickx
 11:30 FA3.02  A Genome-wide CRISPR Screen Using Barcoded-microRNAs Enables Systematic Interrogation of Extracellular Vesicle Biology - Albert Lu
 11:45 FA3.03  Systematic methodological evaluation of a multiplex bead-based flow cytometry assay for detection of extracellular vesicle surface signatures - Andre Gorgens
 12:00 FA3.04  miRNAs Expressed In Brain and Serum Extracellular Vesicles Act as Indicators of Pre-clinical And Clinical Prion Disease - Lesley Cheng 
 12:15 FA3.05  Non-invasive Brain Delivery with Hybrid Extracellular Vesicles (EVs) For Therapy of Machado-Joseph Disease (MJD) - Patricia Albuquerque
12:30 - 12:50 Wrap-up Session
 12:30 Basic Science - Alissa Weaver
12:40 Clinical Aspect - J. Brian Byrd
 12:50 - 13:30 Award Ceremony and Closing Remarks