Cerebrospinal Fluid Task Force

Extracellular vesicles (EVs) were described in the mid-20th century, but interest in EVs intensified by reports in the 1970s from several labs that EVs could transfer RNA and protein cargo between cells. Since then EV studies have rapidly and steadily increased given their potential use as biomarkers or therapeutics for human diseases, including neurological diseases and disorders. The goal of the CSF EV task force is to develop recommendations for rigor and standardization of CSF EV studies based on a survey of current practices and procedures, and a comprehensive review of published studies.

Working Groups

  • CSF Collection, Processing and Storage
  • CSF EV:
    • Enrichment
    • Size & Number
    • Protein Analysis
    • RNA Analysis
    • Glycomic, Lipidomic, and Metabolomic Analysis
    • Functional Assays

Chair Contact Info


  • CSF EV survey and data analysis
  • Literature curation and review (>160 CSF EV original research articles), September 2022


  • Manuscript in progress


Júlia Costa | Beth Coyle | Elizabeth CM de Lange | Juan M. Falcón-Perez | Andrew Hill | Andy Hoffman | Tsuneya Ikezu | Hannah Jackson | Setty Magana | Lisette Retana Moreira | Rienk Nieuwland | John Nolan | Joseph Quinn | Ursula Sandau | Julie Saugstad | Shivani Sharma | Eric Sribnick | Roosmarijn Vandenbroucke | Kendall Van Keuren-Jensen | Laura Vella | Kostas Vekrellis | Kenneth Witwer