Rigor & Standardization Intersociety Working Groups

To improve reproducibility, ISEV collaborates with other international societies. At present, there are three intersociety working groups, the ISEV-ISAC-ISTH EV Flow cytometry working group, the ISEV-ISCT working group, and the ISEV-ELBS working group. Whereas a Task force usually has ISEV members only, intersociety working groups have members from two or more international scientific organizations.

The ISEV-ISAC-ISTH EV Flow Cytometry Intersociety Working Group, founded in 2015, is a collaboration between EV flow cytometry experts from ISEV, the International Society on Advancement of Cytometry (ISAC), and the International Society on Thrombosis and Haemostasis (ISTH). Together, these experts aim to improve the rigor and standardization of EV flow cytometry. To achieve this goal, they organize webinars, have produced a framework for transparent reporting that is supported by ISEV, ISAC and ISTH, and they have produced an educational compendium that provides extensive background information on the detection of EVs by flow cytometry.

Output of the EV Flow Cytometry Working Group

• Educational compendium Published in JEV 2023
• Minimum information to report about a flow cytometry experiment on extracellular vesicles: Communication from the ISTH SSC subcommittee on vascular biology Published in Journal of Thrombosis and Haemostasis 2022
• MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments Published JEV 2020
• MIFlowCyt-EV: The Next Chapter in the Reporting and Reliability of Single Extracellular Vesicle Flow Cytometry Experiments Published in Cytometry A 2021

The ISEV-ISCT Intersociety Working Group on Extracellular vesicles is a collaboration between ISEV and the International Society for Cell and Gene Therapy (ISCT). EVs secreted by stem cells constitute a novel therapeutic entity which offer great opportunities for therapy. Together, ISEV and ISCT collaborate and discuss standardization and regulatory aspects, co-organize sessions at respective annual meetings, and comment on the important developments in the field. All these activities help to foster the clinical applicability of EVs secreted by stem cells, and will facilitate the uptake of developed knowledge by the society.

Output of the ISEV-ISCT Working Group

• International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19 Published in Cytotherapy 2020

The ISEV-ELBS Intersociety Working Group was founded in 2023. ELBS is the European Liquid Biopsy Society, and this working group aims to improve the quality of biobanks used for clinical biomarker exploration, which includes EV-related biomarker research. In the last 20 years, there has been a revolution in early diagnosis, prognosis and therapeutic efficacy of diseases based on information collected from non-invasive liquid biopsies.  

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