Blood EVsThis is an archival page for the event. "Blood EVs" was an ISEV Workshop on all things related to extracellular vesicles of blood: how to obtain, profile, and use them. The event was held in Helsinki, Finland, from 1-2 September 2022 and was preceded by an Education Day on 31 August. The Workshop was in-person only, and participants had already been selected and notified. However, there was a virtual option for Education Day. Download the full program or view below. Short talks and roundtable discussions revolved around four themes: Day 1. Blood EVs as biomarkers
Day 2. Blood EVs as therapeutics
Only ISEV members may attend the Workshop; if you have been invited and are not a member, please visit https://www.isev.org/page/Membership to sign up. A poll on EV practices will be sent out in advance of the meeting. Workshop Chairs and Organizing CommitteeSaara Laitinen Full Program (as of 26 Aug 22)ISEV WORKSHOP – Blood EVs Educational Day 9:00-9.15 General welcome to the Educational day & Blood EV workshop (Saara Laitinen, Finnish Red Cross Blood Service & Pia Siljander, University of Helsinki) 9:15-9:45 Introduction to blood EVs (Rienk Nieuwland, Academic Medical Centre Amsterdam) 9:45-10:15 Blood as a source of EVs (Edit Buzas, Semmelweis University) 10:15- 10.45 Detection methods for EVs in blood (Ken Witwer, John Hopkins University) 10:45-11:20 BREAK 11:20-11:50 Pre-analytical considerations for blood collection and processing in translational and clinical EV research (Fabrice Lucien-Matteoni, Mayo Clinic) 11:50- 12:20 A clinician's perspective on blood EV biomarkers (Aleksandra Gasecka, Medical University of Warsaw & Academic Medical Centre Amsterdam) 12:20-13:05 Company presentations (Izon, ParticleMetrix, TimeGate Instruments, BioNavis, Carmine Therapeutics) 14.00-14:30 Reference values of blood EVs (Metka Lenassi, University of Ljubljana) 14:30-15:00 Approaching clinical feasibility with EV flow cytometry (Edwin van der Pol, Academic Medical Centre Amsterdam) 15:00- 15:20 Company presentations (Luminex, Sartorius) 15:20-15:50 BREAK 15:50-16.20 Heterogeneous platelet-EVs: theranostic opportunities? (Pia Siljander, University of Helsinki) 16:20-16:50 Post-isolation modifications of EVs for therapeutic purposes (Minh Le, National University of Singapore) 16:50-17:20 Summary and discussion (Rienk Nieuwland, Academic Medical Centre Amsterdam) 17:20-18:00 Results of the attendant survey & the blood EV analyses by participating technologies 19.00 Welcome reception at the Botanic gardens
sponsored by Finnish Red Cross Blood Service and HansaBioMed Life Sciences
ISEV WORKSHOP on BLOOD EVs DAY 1 Program Blood EVs – matrix prerequisites & technologies & biomarkers 9:00-9:10 Introduction to working in the workshops, Pia Siljander 9:10-9:25 Introduction to the topic: Blood as a source of EVs Part I (Edit Buzas & Rienk Nieuwland)
5 minutes break
11:10-11:15 Break and organization into three roundtables 11:15-12:30 Roundtable discussions (60’+ 15’ wrap-up in writing by the moderators) Topics will raise organically from the participants/ electronic platform or by the chairs, for example
Table 1 Moderators: Rienk Nieuwland/Pia Siljander Table 2 Moderators: John Nolan/Edwin van der Pol Table 3 Moderators: Ann Hendrix/Metka Lenassi LUNCH 12:30-13:30 13:30-14:00 Highlights from the morning discussions by roundtable moderators (3 x 5 minutes & audience) 14:00-14:15 Introduction to the topic: Biomarker applications of the blood EV surface Part I (Lorraine O’Driscoll, Trinity College)
14:55-15:25 COFFEE Biomarker applications of the blood EV surface Part II
10 minutes break & moving to roundtables 16:10-17:25 Roundtable discussions (60’+ 15’ wrap-up in writing by the moderators) Topics will raise organically from the participants/ electronic platform or by the chairs Table 1 Moderators Lorraine O’Driscoll/Natasha Zavroni Table 2 Moderators Annalisa Radeghieri/Mari Palviainen Table3 Moderators Ken Witwer/Fabrice Lucien-Matteoni 5 minutes break & moving to main hall 17:30-18:00 Highlights shared from the afternoon discussions (3 x 5 min & audience) ISEV WORKSHOP on BLOOD EVs DAY 2 Program Blood EVs as Therapeutics 9.00-9.30 Introduction to topics: Blood as a therapeutic EV source and in delivery of EV-therapy Standing on the shoulders of giants, decades of transfusion & blood cell therapy (Saara Laitinen, Finnish Red Cross Blood Service) Potential therapeutic applications of blood cell derived EVs (Minh Le, National University of Singapore)
11.00-11.15 Break and organization into three roundtables Suggestions for roundtable discussion topics in addition to those which are raised organically
11.15-13.00 Roundtable discussions Roundtable 1 Red blood cell -derived nanobiotechnology Roundtable 2 Different blood cell derived EVs for therapy development Roundtable 3 Lessons learned from blood EVs: is there advantage? LUNCH 13:00 – 14:00 14:00-15:00 Wrap-up the Roundtables (Big hall) 15:00 Coffee 15:30-17:00 Summary of the Workshop Days 1 & 2 Moderators: Saara Laitinen & Pia Siljander & Rienk Nieuwland Wrap up of the three days into deliverables
What should we have discussed and what next? |